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Statistics colloquium talk at the University of Iceland will be given on Thursday, March 13th 2014, at 12:00, see details below.
Speaker: Jóhanna Jakobsdóttir, Researcher at the Icelandic Heart Association
Title: Mixed-Model Association Mapping of Quantitative Traits in Samples with Related Individuals
Location: Room V-157 in building VR-II on the UI campus
Time: Thursday, March 13th 2014, at 12:00 to 13:00.
Abstract: Genetic association studies commonly use samples of unrelated individuals with no known familial relationships. When data on related individuals are available, power can be gained by including all individuals in the analysis, while properly accounting for the dependence among them. We propose MASTOR, a mixed-model, retrospective, score test for genetic association with a quantitative trait. MASTOR achieves high power in samples that contain related individuals by making full use of the relationship information to incorporate partially missing data in the analysis, while correcting for dependence.
